80.Restricted ingredients in cosmetic and skin care products

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Restricted ingredients in cosmetic and skin care products by regulation. Ingredient Potential toxicity Hexachlorophene Neurotoxic effects Ability to penetrate human skin Mercury compounds Accumulation in the body Skin irritation Allergic reactions Neurotoxicity Bithionol Photocontact sensitization Halogenated salicylanilides Photocontact sensitization Chlorofluorocarbon propellants Hazardous to human health Chloroform Plausible carcinogenicity Vinyl chloride Plausible carcinogenicity Zirconium-containing complexes Lung toxicity Methylene chloride Plausible carcinogenicity help to find the specific skincare product ingredients by "skin+" App.
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29-.How do absorption act in the skin ?

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How do absorption act in the skin ?


How do absorption act in the skin ?

Ref. B.W. barry, the transdermal route for the delivery of peptides and proteins, plenum press new Yord 1986

We care about the absorption after applying skincare products and cosmetics, especially the cosmeceuticals (cosmetics+pharmaceuticals). We call it “percutaneous absorption”.
percutaneous absorption has 3 ways
1.     Go through the hair and sweat pores
Most of the medicines and few cosmetics
2.     Through gap of keratinocytes
Most of cosmetics
3.     Pass stratum corneum and go to the deeper layers of epidermis
Only the small molecular weight of substance could pass, such that most of cosmetics cannot pass.

Most of cosmetics take effect through the gap of keratinocytes. The effect depends on ingredients. So adding cyclopentadecanone and cyclopentadecanolide in cosmetics to help penetration is the ways nowadays.
Ref. B.W. barry, the transdermal route for the delivery of peptides and proteins, plenum press new Yord 1986

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